Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors

[Display omitted] A matched and mixed capping SAR study was conducted on the tetracyclic indole class of HCV NS5A inhibitors to examine the influence of modifications of this region on the overall HCV virologic resistance profiles.

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-08, Vol.26 (16), p.4106-4111
Hauptverfasser:	Dwyer, Michael P., Keertikar, Kerry M., Chen, Lei, Tong, Ling, Selyutin, Oleg, Nair, Anilkumar G., Yu, Wensheng, Zhou, Guowei, Lavey, Brian J., Yang, De-Yi, Wong, Michael, Kim, Seong Heon, Coburn, Craig A., Rosenblum, Stuart B., Zeng, Qingbei, Jiang, Yueheng, Shankar, Bandarpalle B., Rizvi, Razia, Nomeir, Amin A., Liu, Rong, Agrawal, Sony, Xia, Ellen, Kong, Rong, Zhai, Ying, Ingravallo, Paul, Asante-Appiah, Ernest, Kozlowski, Joseph A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - chemistry Antiviral Agents - metabolism Antiviral Agents - pharmacology Area Under Curve Capping Genotype Half-Life Hepacivirus - drug effects Hepacivirus - genetics Hepacivirus - metabolism Hepatitis C Hepatitis C virus Indole Indoles - chemistry Indoles - metabolism Indoles - pharmacology Infectious diseases NS5A Rats ROC Curve Structure-Activity Relationship Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - metabolism
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Beschreibung
Zusammenfassung:	[Display omitted] A matched and mixed capping SAR study was conducted on the tetracyclic indole class of HCV NS5A inhibitors to examine the influence of modifications of this region on the overall HCV virologic resistance profiles.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2016.06.063