Female Reproductive Factors, Gene Polymorphisms in the Estrogen Metabolism Pathway, and Risk of Lung Cancer in Chinese Women

The authors examined relations between reproductive factors and 5 estrogen pathway gene polymorphisms (CYP17 rs743572, CYP19A1 rs10046, ERβ rs1256049, ERβ rs4986938, and COMT rs4680) among 702 Singapore Chinese female lung cancer cases and 1,578 hospital controls, of whom 433 cases (61.7%) and 1,375...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of epidemiology 2012-03, Vol.175 (6), p.492-503
Hauptverfasser:	Lim, Wei-Yen, Chen, Ying, Chuah, Khoon Leong, Eng, Philip, Leong, Swan Swan, Lim, Elaine, Lim, Tow Keang, Ng, Alan, Poh, Wee Teng, Tee, Augustine, Teh, Ming, Salim, Agus, Seow, Adeline
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aromatase - genetics Asian Continental Ancestry Group - genetics Biological and medical sciences Case-Control Studies Catechol O-Methyltransferase - genetics China - ethnology Epidemiology Estrogen Receptor beta - genetics Estrogens Female General aspects Genetic Markers Genotyping Techniques Humans Logistic Models Lung cancer Lung Neoplasms - etiology Lung Neoplasms - genetics Medical sciences Menstrual Cycle Middle Aged Miscellaneous Odds Ratio Parity Pneumology Polymorphism Polymorphism, Single Nucleotide Public health. Hygiene Public health. Hygiene-occupational medicine Reproductive system Singapore Smoking - adverse effects Steroid 17-alpha-Hydroxylase - genetics Tumors Tumors of the respiratory system and mediastinum Womens health
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The authors examined relations between reproductive factors and 5 estrogen pathway gene polymorphisms (CYP17 rs743572, CYP19A1 rs10046, ERβ rs1256049, ERβ rs4986938, and COMT rs4680) among 702 Singapore Chinese female lung cancer cases and 1,578 hospital controls, of whom 433 cases (61.7%) and 1,375 controls (87.1%) were never smokers. Parity (per child, odds ratio (OR) = 0.92, 95% confidence interval (CI): 0.87, 0.97) and menstrual cycle length (for ≥30 days vs.
ISSN:	0002-9262 1476-6256
DOI:	10.1093/aje/kwr332