The c-terminal region of reelin is necessary for proper positioning of a subset of purkinje cells in the postnatal cerebellum
Highlights • Tens of Purkinje cells are located ectopically in mice that lack the Reelin C-terminal region. • Ectopic PCs are selectively found in the lobule VI/VII and often form clusters. • Insufficient cell-autonomous Reelin signaling is likely to cause the ectopicity. • Reelin protein with intac...
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Veröffentlicht in: | Neuroscience 2016-11, Vol.336, p.20-29 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Highlights • Tens of Purkinje cells are located ectopically in mice that lack the Reelin C-terminal region. • Ectopic PCs are selectively found in the lobule VI/VII and often form clusters. • Insufficient cell-autonomous Reelin signaling is likely to cause the ectopicity. • Reelin protein with intact CTR binds preferentially to Purkinje cells. |
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ISSN: | 0306-4522 1873-7544 |
DOI: | 10.1016/j.neuroscience.2016.08.039 |