The c-terminal region of reelin is necessary for proper positioning of a subset of purkinje cells in the postnatal cerebellum

Highlights • Tens of Purkinje cells are located ectopically in mice that lack the Reelin C-terminal region. • Ectopic PCs are selectively found in the lobule VI/VII and often form clusters. • Insufficient cell-autonomous Reelin signaling is likely to cause the ectopicity. • Reelin protein with intac...

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Veröffentlicht in:Neuroscience 2016-11, Vol.336, p.20-29
Hauptverfasser: Nakamura, Kota, Beppu, Mako, Sakai, Kaori, Yagyu, Hayata, Matsumaru, Saori, Kohno, Takao, Hattori, Mitsuharu
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Sprache:eng
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Zusammenfassung:Highlights • Tens of Purkinje cells are located ectopically in mice that lack the Reelin C-terminal region. • Ectopic PCs are selectively found in the lobule VI/VII and often form clusters. • Insufficient cell-autonomous Reelin signaling is likely to cause the ectopicity. • Reelin protein with intact CTR binds preferentially to Purkinje cells.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.08.039