Temporal development of baroreceptor dysfunction in a rodent model of chronic kidney disease

Summary Altered autonomic control of the cardiovascular system in chronic kidney disease (CKD) contributes to an increased risk of cardiovascular events. The aim of the present study was to determine whether and when autonomic dysfunction occurs in a conscious, telemetered, rodent model of CKD. In L...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2013-07, Vol.40 (7), p.458-465
Hauptverfasser:	Hildreth, Cara M, Kandukuri, Divya Sarma, Goodchild, Ann K, Phillips, Jacqueline K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autonomic Nervous System - physiopathology baroreflex Baroreflex - physiology Blood Pressure - physiology Cardiovascular System - physiopathology Disease Models, Animal Heart Rate - physiology heart rate variability Male polycystic kidney disease Polycystic Kidney Diseases - physiopathology Pressoreceptors - physiopathology Rats Rats, Inbred Lew Renal Insufficiency, Chronic - physiopathology systolic blood pressure variability telemetry
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Zusammenfassung:	Summary Altered autonomic control of the cardiovascular system in chronic kidney disease (CKD) contributes to an increased risk of cardiovascular events. The aim of the present study was to determine whether and when autonomic dysfunction occurs in a conscious, telemetered, rodent model of CKD. In Lewis polycystic kidney (LPK; n = 8) and Lewis (n = 8) rats, blood pressure (BP), heart rate (HR), HR variability (HRV), systolic BP variability (SBPV) and baroreflex sensitivity (BRS) were determined from 10 to 16 weeks of age. The LPK rats had higher systolic BP (average across all ages: 230 ± 10 vs 122.6 ± 0.3 mmHg; P
ISSN:	0305-1870 1440-1681
DOI:	10.1111/1440-1681.12110