Structure and proposed mechanism of l‐α‐glycerophosphate oxidase from Mycoplasma pneumoniae

The formation of H2O2 by the FAD‐dependent l‐α‐glycerophosphate oxidase (GlpO) is important for the pathogenesis of Streptococcus pneumoniae and Mycoplasma pneumoniae. The structurally known GlpO from Streptococcus sp. (SspGlpO) is similar to the pneumococcal protein (SpGlpO) and provides a guide fo...

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Veröffentlicht in:	The FEBS journal 2015-08, Vol.282 (16), p.3030-3042
Hauptverfasser:	Elkhal, Callia K., Kean, Kelsey M., Parsonage, Derek, Maenpuen, Somchart, Chaiyen, Pimchai, Claiborne, Al, Karplus, P. Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bordetella pertussis Bordetella pertussis - genetics Bordetella pertussis - metabolism Catalysis Catalytic Domain Crystallography, X-Ray drug design Flavin-Adenine Dinucleotide - metabolism flavoenzyme Genes, Bacterial GlpA Glycerolphosphate Dehydrogenase - chemistry Glycerolphosphate Dehydrogenase - genetics Glycerolphosphate Dehydrogenase - metabolism hydride transfer Models, Molecular Molecular Sequence Data Mycoplasma pneumoniae Mycoplasma pneumoniae - enzymology Mycoplasma pneumoniae - genetics Oxidation-Reduction protein evolution Protein Structure, Tertiary Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Homology, Amino Acid Static Electricity Streptococcus Streptococcus pneumoniae
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Zusammenfassung:	The formation of H2O2 by the FAD‐dependent l‐α‐glycerophosphate oxidase (GlpO) is important for the pathogenesis of Streptococcus pneumoniae and Mycoplasma pneumoniae. The structurally known GlpO from Streptococcus sp. (SspGlpO) is similar to the pneumococcal protein (SpGlpO) and provides a guide for drug design against that target. However, M. pneumoniae GlpO (MpGlpO), having
ISSN:	1742-464X 1742-4658
DOI:	10.1111/febs.13233