Hypo-excitation across all cortical laminae defines intermediate stages of cortical neuronal dysfunction in diffuse traumatic brain injury

Highlights • A rodent model of traumatic brain injury (TBI) was used to assess cortical processing 2 weeks post-injury. • Short-term suppression of neural firing rates had spread from supra to infragranular layers. • TBI induced temporal abnormalities in neural coding and dysfunction in complex stim...

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Veröffentlicht in:	Neuroscience 2016-10, Vol.334, p.290-308
Hauptverfasser:	Allitt, Benjamin J, Iva, Pippa, Yan, Edwin B, Rajan, Ramesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Brain Injuries, Traumatic - physiopathology cortical laminae Disease Models, Animal Disease Progression electrophysiology Male Microelectrodes Motor Activity - physiology Neurology Neurons - physiology Rats, Sprague-Dawley sensory cortex Somatosensory Cortex - injuries Somatosensory Cortex - physiopathology Time Factors Touch Perception - physiology traumatic brain injury Vibrissae - physiology
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Zusammenfassung:	Highlights • A rodent model of traumatic brain injury (TBI) was used to assess cortical processing 2 weeks post-injury. • Short-term suppression of neural firing rates had spread from supra to infragranular layers. • TBI induced temporal abnormalities in neural coding and dysfunction in complex stimuli processing.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.08.018