Anxiety response and restraint-induced stress differentially affect ethanol intake in female adolescent rats

Highlights • Adolescent female Wistar rats with high anxiety drank more ethanol than average counterparts. • The promoting effect of high anxiety on ethanol intake was inhibited by stress. • Restraint stress increased FOS immunoreactivity in paraventricular nucleus. • Stress-induced FOS immunoreacti...

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Veröffentlicht in:	Neuroscience 2016-10, Vol.334, p.259-274
Hauptverfasser:	Acevedo, María Belén, Fabio, Maria Carolina, Fernández, Macarena, Pautassi, Ricardo Marcos
Format:	Artikel
Sprache:	eng
Schlagworte:	adolescents Alcohol Drinking - pathology Alcohol Drinking - physiopathology Alcohol Drinking - psychology Amygdala - metabolism Amygdala - pathology Animals anxiety Anxiety - pathology Anxiety - physiopathology Arcuate Nucleus of Hypothalamus - metabolism Arcuate Nucleus of Hypothalamus - pathology Central Nervous System Depressants - administration & dosage Disease Models, Animal Ethanol - administration & dosage ethanol intake Female Fos immunoreactivity Genetic Predisposition to Disease Multivariate Analysis Neurology Paraventricular Hypothalamic Nucleus - metabolism Paraventricular Hypothalamic Nucleus - pathology Personality Proto-Oncogene Proteins c-fos - metabolism Rats, Wistar Restraint, Physical Self Administration Sexual Maturation stress Stress, Psychological - pathology Stress, Psychological - physiopathology
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Zusammenfassung:	Highlights • Adolescent female Wistar rats with high anxiety drank more ethanol than average counterparts. • The promoting effect of high anxiety on ethanol intake was inhibited by stress. • Restraint stress increased FOS immunoreactivity in paraventricular nucleus. • Stress-induced FOS immunoreactivity was unaffected by level of anxiety response.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.08.011