Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer’s disease
Highlights • Treatment of APP/PS1 mice with antiTLR2 antibody for 7 months improves spatial learning. • Aβ plaque burden is reduced in antiTLR2 antibody-treated APP/PS1 mice. • These changes are associated with decreased microglial activation as indicated by reduced immunoreactivity for CD68. • Anti...
Gespeichert in:
| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2016-11, Vol.58, p.191-200 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 200 |
|---|---|
| container_issue | |
| container_start_page | 191 |
| container_title | Brain, behavior, and immunity |
| container_volume | 58 |
| creator | McDonald, Claire L Hennessy, Edel Araiz, Ana Rubio Keogh, Brian McCormack, William McGuirk, Peter Reilly, Mary Lynch, Marina A |
| description | Highlights • Treatment of APP/PS1 mice with antiTLR2 antibody for 7 months improves spatial learning. • Aβ plaque burden is reduced in antiTLR2 antibody-treated APP/PS1 mice. • These changes are associated with decreased microglial activation as indicated by reduced immunoreactivity for CD68. • Anti-TLR2 antibody treatment reduced GFAP immunoreactivity in hippocampus of APP/PS1 mice. |
| doi_str_mv | 10.1016/j.bbi.2016.07.143 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1837298615</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0889159116303373</els_id><sourcerecordid>1837298615</sourcerecordid><originalsourceid>FETCH-LOGICAL-c507t-ee5b8491b930eb9e53cbe75b6a7771513bff01a41c7d9da0728c581d328dd5663</originalsourceid><addsrcrecordid>eNqNks-KFDEQxoMo7rj6AF6kj166TSWdTjeCsCz-WRgQdD2H_KnZrTHdvXa6F8aTr7Gvt09ihhlFPIiXJKS-76OoXzH2HHgFHJpX28o5qkR-VlxXUMsHbAW846UA2T1kK962XQmqgxP2JKUt51xJaB-zE6FrITToFdtdDNfkaKbhqrhcfxKF9TPd2pnGobDzjMNiZ0yF7XdxpJCrfumXeKwPobiKZOOfJsr_RT8uCfMZMBbjpjiL36-Repzuf9ylIlBCm_Ape7SxMeGz433Kvrx7e3n-oVx_fH9xfrYuveJ6LhGVa-sOXCc5ug6V9A61co3VWoMC6TYbDrYGr0MXLNei9aqFIEUbgmoaecpeHnJvpvHbgmk2PSWPMdoBc5sGWqlF1zag_kMqGi1U3fAshYPUT2NKE27MzUS9nXYGuNnDMVuT4Zg9HMO1yXCy58UxfnE9ht-OXzSy4PVBgHket4STSZ5w8BhoQj-bMNI_49_85faRBvI2fsUdpu24TEMetAGThOHm83479ssBjeRSail_Ar0Otf4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1826725460</pqid></control><display><type>article</type><title>Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer’s disease</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>McDonald, Claire L ; Hennessy, Edel ; Araiz, Ana Rubio ; Keogh, Brian ; McCormack, William ; McGuirk, Peter ; Reilly, Mary ; Lynch, Marina A</creator><creatorcontrib>McDonald, Claire L ; Hennessy, Edel ; Araiz, Ana Rubio ; Keogh, Brian ; McCormack, William ; McGuirk, Peter ; Reilly, Mary ; Lynch, Marina A</creatorcontrib><description>Highlights • Treatment of APP/PS1 mice with antiTLR2 antibody for 7 months improves spatial learning. • Aβ plaque burden is reduced in antiTLR2 antibody-treated APP/PS1 mice. • These changes are associated with decreased microglial activation as indicated by reduced immunoreactivity for CD68. • Anti-TLR2 antibody treatment reduced GFAP immunoreactivity in hippocampus of APP/PS1 mice.</description><identifier>ISSN: 0889-1591</identifier><identifier>EISSN: 1090-2139</identifier><identifier>DOI: 10.1016/j.bbi.2016.07.143</identifier><identifier>PMID: 27422717</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Allergy and Immunology ; Alzheimer Disease - immunology ; Alzheimer Disease - metabolism ; Alzheimer’s disease ; Amyloid beta-Protein Precursor - genetics ; Amyloid-β (Aβ) ; Animals ; Antibodies - administration & dosage ; APP/PS1 mice ; Astrocytes - metabolism ; Astrocytic activation ; Cognitive function ; Disease Models, Animal ; Encephalitis - immunology ; Encephalitis - metabolism ; Female ; Hippocampus - metabolism ; Male ; Maze Learning ; Mice ; Mice, Transgenic ; Microglia - metabolism ; Microglial activation ; Neuroinflammation ; Plaque, Amyloid - metabolism ; Presenilin-1 - genetics ; Psychiatry ; Toll-like receptor 2 (TLR2) ; Toll-Like Receptor 2 - antagonists & inhibitors ; Toll-Like Receptor 2 - immunology ; Toll-Like Receptor 2 - metabolism</subject><ispartof>Brain, behavior, and immunity, 2016-11, Vol.58, p.191-200</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-ee5b8491b930eb9e53cbe75b6a7771513bff01a41c7d9da0728c581d328dd5663</citedby><cites>FETCH-LOGICAL-c507t-ee5b8491b930eb9e53cbe75b6a7771513bff01a41c7d9da0728c581d328dd5663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0889159116303373$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27422717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McDonald, Claire L</creatorcontrib><creatorcontrib>Hennessy, Edel</creatorcontrib><creatorcontrib>Araiz, Ana Rubio</creatorcontrib><creatorcontrib>Keogh, Brian</creatorcontrib><creatorcontrib>McCormack, William</creatorcontrib><creatorcontrib>McGuirk, Peter</creatorcontrib><creatorcontrib>Reilly, Mary</creatorcontrib><creatorcontrib>Lynch, Marina A</creatorcontrib><title>Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer’s disease</title><title>Brain, behavior, and immunity</title><addtitle>Brain Behav Immun</addtitle><description>Highlights • Treatment of APP/PS1 mice with antiTLR2 antibody for 7 months improves spatial learning. • Aβ plaque burden is reduced in antiTLR2 antibody-treated APP/PS1 mice. • These changes are associated with decreased microglial activation as indicated by reduced immunoreactivity for CD68. • Anti-TLR2 antibody treatment reduced GFAP immunoreactivity in hippocampus of APP/PS1 mice.</description><subject>Allergy and Immunology</subject><subject>Alzheimer Disease - immunology</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer’s disease</subject><subject>Amyloid beta-Protein Precursor - genetics</subject><subject>Amyloid-β (Aβ)</subject><subject>Animals</subject><subject>Antibodies - administration & dosage</subject><subject>APP/PS1 mice</subject><subject>Astrocytes - metabolism</subject><subject>Astrocytic activation</subject><subject>Cognitive function</subject><subject>Disease Models, Animal</subject><subject>Encephalitis - immunology</subject><subject>Encephalitis - metabolism</subject><subject>Female</subject><subject>Hippocampus - metabolism</subject><subject>Male</subject><subject>Maze Learning</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Microglia - metabolism</subject><subject>Microglial activation</subject><subject>Neuroinflammation</subject><subject>Plaque, Amyloid - metabolism</subject><subject>Presenilin-1 - genetics</subject><subject>Psychiatry</subject><subject>Toll-like receptor 2 (TLR2)</subject><subject>Toll-Like Receptor 2 - antagonists & inhibitors</subject><subject>Toll-Like Receptor 2 - immunology</subject><subject>Toll-Like Receptor 2 - metabolism</subject><issn>0889-1591</issn><issn>1090-2139</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks-KFDEQxoMo7rj6AF6kj166TSWdTjeCsCz-WRgQdD2H_KnZrTHdvXa6F8aTr7Gvt09ihhlFPIiXJKS-76OoXzH2HHgFHJpX28o5qkR-VlxXUMsHbAW846UA2T1kK962XQmqgxP2JKUt51xJaB-zE6FrITToFdtdDNfkaKbhqrhcfxKF9TPd2pnGobDzjMNiZ0yF7XdxpJCrfumXeKwPobiKZOOfJsr_RT8uCfMZMBbjpjiL36-Repzuf9ylIlBCm_Ape7SxMeGz433Kvrx7e3n-oVx_fH9xfrYuveJ6LhGVa-sOXCc5ug6V9A61co3VWoMC6TYbDrYGr0MXLNei9aqFIEUbgmoaecpeHnJvpvHbgmk2PSWPMdoBc5sGWqlF1zag_kMqGi1U3fAshYPUT2NKE27MzUS9nXYGuNnDMVuT4Zg9HMO1yXCy58UxfnE9ht-OXzSy4PVBgHket4STSZ5w8BhoQj-bMNI_49_85faRBvI2fsUdpu24TEMetAGThOHm83479ssBjeRSail_Ar0Otf4</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>McDonald, Claire L</creator><creator>Hennessy, Edel</creator><creator>Araiz, Ana Rubio</creator><creator>Keogh, Brian</creator><creator>McCormack, William</creator><creator>McGuirk, Peter</creator><creator>Reilly, Mary</creator><creator>Lynch, Marina A</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope></search><sort><creationdate>20161101</creationdate><title>Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer’s disease</title><author>McDonald, Claire L ; Hennessy, Edel ; Araiz, Ana Rubio ; Keogh, Brian ; McCormack, William ; McGuirk, Peter ; Reilly, Mary ; Lynch, Marina A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-ee5b8491b930eb9e53cbe75b6a7771513bff01a41c7d9da0728c581d328dd5663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Allergy and Immunology</topic><topic>Alzheimer Disease - immunology</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer’s disease</topic><topic>Amyloid beta-Protein Precursor - genetics</topic><topic>Amyloid-β (Aβ)</topic><topic>Animals</topic><topic>Antibodies - administration & dosage</topic><topic>APP/PS1 mice</topic><topic>Astrocytes - metabolism</topic><topic>Astrocytic activation</topic><topic>Cognitive function</topic><topic>Disease Models, Animal</topic><topic>Encephalitis - immunology</topic><topic>Encephalitis - metabolism</topic><topic>Female</topic><topic>Hippocampus - metabolism</topic><topic>Male</topic><topic>Maze Learning</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Microglia - metabolism</topic><topic>Microglial activation</topic><topic>Neuroinflammation</topic><topic>Plaque, Amyloid - metabolism</topic><topic>Presenilin-1 - genetics</topic><topic>Psychiatry</topic><topic>Toll-like receptor 2 (TLR2)</topic><topic>Toll-Like Receptor 2 - antagonists & inhibitors</topic><topic>Toll-Like Receptor 2 - immunology</topic><topic>Toll-Like Receptor 2 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McDonald, Claire L</creatorcontrib><creatorcontrib>Hennessy, Edel</creatorcontrib><creatorcontrib>Araiz, Ana Rubio</creatorcontrib><creatorcontrib>Keogh, Brian</creatorcontrib><creatorcontrib>McCormack, William</creatorcontrib><creatorcontrib>McGuirk, Peter</creatorcontrib><creatorcontrib>Reilly, Mary</creatorcontrib><creatorcontrib>Lynch, Marina A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Brain, behavior, and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McDonald, Claire L</au><au>Hennessy, Edel</au><au>Araiz, Ana Rubio</au><au>Keogh, Brian</au><au>McCormack, William</au><au>McGuirk, Peter</au><au>Reilly, Mary</au><au>Lynch, Marina A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer’s disease</atitle><jtitle>Brain, behavior, and immunity</jtitle><addtitle>Brain Behav Immun</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>58</volume><spage>191</spage><epage>200</epage><pages>191-200</pages><issn>0889-1591</issn><eissn>1090-2139</eissn><abstract>Highlights • Treatment of APP/PS1 mice with antiTLR2 antibody for 7 months improves spatial learning. • Aβ plaque burden is reduced in antiTLR2 antibody-treated APP/PS1 mice. • These changes are associated with decreased microglial activation as indicated by reduced immunoreactivity for CD68. • Anti-TLR2 antibody treatment reduced GFAP immunoreactivity in hippocampus of APP/PS1 mice.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>27422717</pmid><doi>10.1016/j.bbi.2016.07.143</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0889-1591 |
| ispartof | Brain, behavior, and immunity, 2016-11, Vol.58, p.191-200 |
| issn | 0889-1591 1090-2139 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1837298615 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergy and Immunology Alzheimer Disease - immunology Alzheimer Disease - metabolism Alzheimer’s disease Amyloid beta-Protein Precursor - genetics Amyloid-β (Aβ) Animals Antibodies - administration & dosage APP/PS1 mice Astrocytes - metabolism Astrocytic activation Cognitive function Disease Models, Animal Encephalitis - immunology Encephalitis - metabolism Female Hippocampus - metabolism Male Maze Learning Mice Mice, Transgenic Microglia - metabolism Microglial activation Neuroinflammation Plaque, Amyloid - metabolism Presenilin-1 - genetics Psychiatry Toll-like receptor 2 (TLR2) Toll-Like Receptor 2 - antagonists & inhibitors Toll-Like Receptor 2 - immunology Toll-Like Receptor 2 - metabolism |
| title | Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer’s disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T23%3A57%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inhibiting%20TLR2%20activation%20attenuates%20amyloid%20accumulation%20and%20glial%20activation%20in%20a%20mouse%20model%20of%20Alzheimer%E2%80%99s%20disease&rft.jtitle=Brain,%20behavior,%20and%20immunity&rft.au=McDonald,%20Claire%20L&rft.date=2016-11-01&rft.volume=58&rft.spage=191&rft.epage=200&rft.pages=191-200&rft.issn=0889-1591&rft.eissn=1090-2139&rft_id=info:doi/10.1016/j.bbi.2016.07.143&rft_dat=%3Cproquest_cross%3E1837298615%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1826725460&rft_id=info:pmid/27422717&rft_els_id=1_s2_0_S0889159116303373&rfr_iscdi=true |