Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer’s disease

Highlights • Treatment of APP/PS1 mice with antiTLR2 antibody for 7 months improves spatial learning. • Aβ plaque burden is reduced in antiTLR2 antibody-treated APP/PS1 mice. • These changes are associated with decreased microglial activation as indicated by reduced immunoreactivity for CD68. • Anti...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-11, Vol.58, p.191-200
Hauptverfasser:	McDonald, Claire L, Hennessy, Edel, Araiz, Ana Rubio, Keogh, Brian, McCormack, William, McGuirk, Peter, Reilly, Mary, Lynch, Marina A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Alzheimer Disease - immunology Alzheimer Disease - metabolism Alzheimer’s disease Amyloid beta-Protein Precursor - genetics Amyloid-β (Aβ) Animals Antibodies - administration & dosage APP/PS1 mice Astrocytes - metabolism Astrocytic activation Cognitive function Disease Models, Animal Encephalitis - immunology Encephalitis - metabolism Female Hippocampus - metabolism Male Maze Learning Mice Mice, Transgenic Microglia - metabolism Microglial activation Neuroinflammation Plaque, Amyloid - metabolism Presenilin-1 - genetics Psychiatry Toll-like receptor 2 (TLR2) Toll-Like Receptor 2 - antagonists & inhibitors Toll-Like Receptor 2 - immunology Toll-Like Receptor 2 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Treatment of APP/PS1 mice with antiTLR2 antibody for 7 months improves spatial learning. • Aβ plaque burden is reduced in antiTLR2 antibody-treated APP/PS1 mice. • These changes are associated with decreased microglial activation as indicated by reduced immunoreactivity for CD68. • Anti-TLR2 antibody treatment reduced GFAP immunoreactivity in hippocampus of APP/PS1 mice.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.07.143