Characterization of evolutionary trend in squamate estrogen receptor sensitivity
Highlights • Estrogen receptors from three squamates were functionally characterized. • Comparisons of ligand sensitivities suggest an evolutionary trend in vertebrate ERα • Squamates have high ligand sensitivity, while urodeles have low sensitivity. • Homology models also suggest similar trend in m...
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| Veröffentlicht in: | General and comparative endocrinology 2016-11, Vol.238, p.88-95 |
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| container_title | General and comparative endocrinology |
| container_volume | 238 |
| creator | Yatsu, Ryohei Katsu, Yoshinao Kohno, Satomi Mizutani, Takeshi Ogino, Yukiko Ohta, Yasuhiko Myburgh, Jan van Wyk, Johannes H Guillette, Louis J Miyagawa, Shinichi Iguchi, Taisen |
| description | Highlights • Estrogen receptors from three squamates were functionally characterized. • Comparisons of ligand sensitivities suggest an evolutionary trend in vertebrate ERα • Squamates have high ligand sensitivity, while urodeles have low sensitivity. • Homology models also suggest similar trend in molecular ligand binding affinity. |
| doi_str_mv | 10.1016/j.ygcen.2016.04.005 |
| format | Article |
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| ispartof | General and comparative endocrinology, 2016-11, Vol.238, p.88-95 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amino Acid Sequence Animals Biological Evolution Cloning, Molecular Computer Simulation Endocrinology & Metabolism Estrogen Receptor alpha - chemistry Estrogen Receptor alpha - metabolism Estrogen Receptor beta - metabolism Gekko Lacertilia Ligands Lizards - metabolism Models, Molecular Protein Domains Receptors, Estrogen - chemistry Receptors, Estrogen - metabolism Transcription, Genetic |
| title | Characterization of evolutionary trend in squamate estrogen receptor sensitivity |
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