Characterization of evolutionary trend in squamate estrogen receptor sensitivity

Highlights • Estrogen receptors from three squamates were functionally characterized. • Comparisons of ligand sensitivities suggest an evolutionary trend in vertebrate ERα • Squamates have high ligand sensitivity, while urodeles have low sensitivity. • Homology models also suggest similar trend in m...

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Veröffentlicht in:	General and comparative endocrinology 2016-11, Vol.238, p.88-95
Hauptverfasser:	Yatsu, Ryohei, Katsu, Yoshinao, Kohno, Satomi, Mizutani, Takeshi, Ogino, Yukiko, Ohta, Yasuhiko, Myburgh, Jan, van Wyk, Johannes H, Guillette, Louis J, Miyagawa, Shinichi, Iguchi, Taisen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological Evolution Cloning, Molecular Computer Simulation Endocrinology & Metabolism Estrogen Receptor alpha - chemistry Estrogen Receptor alpha - metabolism Estrogen Receptor beta - metabolism Gekko Lacertilia Ligands Lizards - metabolism Models, Molecular Protein Domains Receptors, Estrogen - chemistry Receptors, Estrogen - metabolism Transcription, Genetic
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights • Estrogen receptors from three squamates were functionally characterized. • Comparisons of ligand sensitivities suggest an evolutionary trend in vertebrate ERα • Squamates have high ligand sensitivity, while urodeles have low sensitivity. • Homology models also suggest similar trend in molecular ligand binding affinity.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2016.04.005