Effect of Sodium Metabisulphite on Blood Metabolic Status of Wistar Rats

The objective of this work was to determine the sodium metabisulphite (NaMBS) subchronic toxicity used as a food additive in Algeria. Three groups of female Wistar rats were treated with 0.25%, 1% and 4% of NaMBS in their drinking water for 90 days. An immunization protocol was conducted during the experiment. At the end of the experiment, the control and experiment rats were killed, and their blood and organs were removed. Immunoglobulin levels were evaluated; biochemical and hematological parameters were investigated. The results showed that the administration of NaMBS at 1% and 4% had significant effects on body weight, food and water consumed. There was an increase in biochemical parameters and decrease immunoglobulin levels. The hematology revealed a decrease in red blood cells and hemoglobin, as well as leucocytosis. Physiological study showed enlarged spleen, kidney, liver and stomach. In light of the results, the researchers can conclude that subchronic intake of NaMBS 1% and 4% seems to alter immune function, biochemical, hematological and physiological parameters in Wistar rats.