Immunohistochemical analysis of the hypothalamic-pituitary-adrenal axis in dogs: Sex-linked and seasonal variation

Immunohistochemical analysis of the hypothalamic-pituitary-adrenal axis in dogs: Sex-linked and seasonal variation

This study evaluated sexual dimorphism and seasonal variations in corticotrophs and adrenal zona fasciculata in dogs, as well as the expression of oestrogen receptor alpha (ERα). An immunohistochemical analysis was conducted in pituitaries for ACTH and in adrenal glands for ERα and for the melanocor...

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Veröffentlicht in:Research in veterinary science 2016-02, Vol.104, p.10-16
Hauptverfasser: Gallelli, M.F., Lombardo, D., Vissio, P., Quiroga, A., Caggiano, N., Soler, E., Meikle, A., Castillo, V.A.
Format: Artikel
Sprache:eng
Schlagworte:
Adrenal cortex
Adrenal glands
Age
Animal euthanasia
Animals
Binding sites
Colleges & universities
Corticotroph
Dogs - anatomy & histology
Estrogen Receptor alpha - genetics
Estrogen Receptor alpha - metabolism
Female
Females
Hypothalamo-Hypophyseal System - chemistry
Hypothalamo-Hypophyseal System - metabolism
Hypothalamo-Hypophyseal System - physiology
Immunohistochemistry - veterinary
Male
Males
Melanocortin 2 receptor (MC2R)
Metabolism
Morphology
Oestrogen receptor
Pituitary gland
Pituitary-Adrenal System - chemistry
Pituitary-Adrenal System - metabolism
Pituitary-Adrenal System - physiology
Rodents
Seasons
Sex Characteristics
Sexual dimorphism
Sheep
Summer
Veterinary medicine
Winter
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Beschreibung
Zusammenfassung:This study evaluated sexual dimorphism and seasonal variations in corticotrophs and adrenal zona fasciculata in dogs, as well as the expression of oestrogen receptor alpha (ERα). An immunohistochemical analysis was conducted in pituitaries for ACTH and in adrenal glands for ERα and for the melanocortin-2-receptor (MC2R) in winter and summer. Double immunofluorescence was performed to identify ERα in corticotrophs. Females had a greater proportion of corticotrophs per field (p
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2015.11.003