Positive regulation of HIF-1A expression by EBV oncoprotein LMP1 in nasopharyngeal carcinoma cells

Highlights • LMP1 up-regulates HIF-1A transcription and post-transcription in NPC cells. • Down-regulation of RNA-destabilizing proteins contributes to stabilize HIF-1α mRNA. • LMP1 facilitates HIF-1A promoter activity and positive auto-regulation of HIF-1α.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2016-11, Vol.382 (1), p.21-31
Hauptverfasser:	Sung, Wei-Wen, Chu, Yi-Chih, Chen, Peir-Rong, Liao, Ming-Hui, Lee, Jeng-Woei
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Angiogenesis Binding Sites Carcinoma - genetics Carcinoma - metabolism Carcinoma - virology Cell growth Cell Line, Tumor Cell Transformation, Viral Colleges & universities Conflicts of interest EBV Epigenetics Epstein-Barr virus Epstein-Barr Virus Infections - genetics Epstein-Barr Virus Infections - metabolism Epstein-Barr Virus Infections - virology Extracellular Signal-Regulated MAP Kinases Gene expression Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Hepatitis Herpesvirus 4, Human - genetics Herpesvirus 4, Human - metabolism HIF-1α Host-Pathogen Interactions Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Infections Kinases LMP-1 MicroRNAs Mutagenesis Mutation Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - virology NF-kappa B - metabolism Plasmids Proteins RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Rodents Signal Transduction STAT3 Transcription Factor - metabolism Time Factors Transcription, Genetic Transfection Tristetraprolin - genetics Tristetraprolin - metabolism Up-Regulation Viral Matrix Proteins - genetics Viral Matrix Proteins - metabolism Viruses
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Beschreibung
Zusammenfassung:	Highlights • LMP1 up-regulates HIF-1A transcription and post-transcription in NPC cells. • Down-regulation of RNA-destabilizing proteins contributes to stabilize HIF-1α mRNA. • LMP1 facilitates HIF-1A promoter activity and positive auto-regulation of HIF-1α.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.08.021