A dynamic course of T cell defects in individuals at risk for mood disorders

Highlights • A subtle, partial T cell deficiency has been found in bipolar offspring over time. • T cell subsets followed a dynamic course from adolescence into adulthood. • During adolescence, a high inflammatory state was detected in bipolar offspring. • T cell aberrancies do not directly predict...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-11, Vol.58, p.11-17
Hauptverfasser:	Snijders, G, Schiweck, C, Mesman, E, Grosse, L, De Wit, H, Nolen, W.A, Drexhage, H.A, Hillegers, M.H.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Allergy and Immunology Bipolar disorder Bipolar Disorder - genetics Child Female Gene Expression Genetic Predisposition to Disease High risk Humans Inflammation Inflammation - complications Inflammation - immunology Killer Cells, Natural - metabolism Male Monocytes - metabolism Mood disorder Mood Disorders - complications Mood Disorders - genetics Mood Disorders - immunology Natural T regulatory cells Psychiatry T cells T-Lymphocyte Subsets - metabolism Young Adult
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Beschreibung
Zusammenfassung:	Highlights • A subtle, partial T cell deficiency has been found in bipolar offspring over time. • T cell subsets followed a dynamic course from adolescence into adulthood. • During adolescence, a high inflammatory state was detected in bipolar offspring. • T cell aberrancies do not directly predict mood disorder development.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.05.007