Urinary orosomucoid: a novel, early biomarker of sepsis with promising diagnostic performance

In order to help clinical decision making, we investigated the diagnostic and prognostic ability of urinary orosomucoid (u-ORM) as a new sepsis biomarker, and compared its performance to classical inflammatory parameters. We monitored u-ORM in septic (n=43) and SIRS (n=13) patients in a 5-day follow...

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Veröffentlicht in:Clinical chemistry and laboratory medicine 2017-02, Vol.55 (2), p.299-307
Hauptverfasser: Kustán, Péter, Szirmay, Balázs, Horváth-Szalai, Zoltán, Ludány, Andrea, Kovács, Gábor L., Miseta, Attila, Kőszegi, Tamás, Mühl, Diána
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Sprache:eng
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Zusammenfassung:In order to help clinical decision making, we investigated the diagnostic and prognostic ability of urinary orosomucoid (u-ORM) as a new sepsis biomarker, and compared its performance to classical inflammatory parameters. We monitored u-ORM in septic (n=43) and SIRS (n=13) patients in a 5-day follow-up study vs. control patients (n=30). U-ORM was measured by a newly developed turbidimetric assay. U-ORM values were referred to urinary creatinine and expressed as u-ORM/u-CREAT (mg/mmol). Significantly higher (p
ISSN:1434-6621
1437-4331
DOI:10.1515/cclm-2016-0840