Urinary orosomucoid: a novel, early biomarker of sepsis with promising diagnostic performance
In order to help clinical decision making, we investigated the diagnostic and prognostic ability of urinary orosomucoid (u-ORM) as a new sepsis biomarker, and compared its performance to classical inflammatory parameters. We monitored u-ORM in septic (n=43) and SIRS (n=13) patients in a 5-day follow...
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Veröffentlicht in: | Clinical chemistry and laboratory medicine 2017-02, Vol.55 (2), p.299-307 |
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Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | In order to help clinical decision making, we investigated the diagnostic and prognostic ability of urinary orosomucoid (u-ORM) as a new sepsis biomarker, and compared its performance to classical inflammatory parameters.
We monitored u-ORM in septic (n=43) and SIRS (n=13) patients in a 5-day follow-up study vs. control patients (n=30). U-ORM was measured by a newly developed turbidimetric assay. U-ORM values were referred to urinary creatinine and expressed as u-ORM/u-CREAT (mg/mmol).
Significantly higher (p |
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ISSN: | 1434-6621 1437-4331 |
DOI: | 10.1515/cclm-2016-0840 |