Impact of Number of Cycles of Collagenase Clostridium Histolyticum on Outcomes in Patients with Peyronie's Disease

Abstract Objective To analyze the impact of the number of cycles of collagenase Clostridium histolyticum (CCH) intralesional injection therapy on outcomes in order to further characterize CCH therapy. Methods We conducted a retrospective review of the records of all patients treated with CCH for PD between 04/2014 and 03/2016. Collected variables included demographics, pre- and post-treatment sexual function, penile curvature, penile vascular findings, and treatment outcomes. Results A total of 77 patients were included in the study, of which 41 (53%) completed four cycles of treatment, consisting of eight total injections. For all-comers regardless of numbers of cycles, curvature improved from 58.2° (SD=17.9°, range=30-105°) pre-treatment to 41.0 degrees (SD=17.0°, range=0-85°) post-treatment (p