Establishment and gene expression analysis of disease-derived induced pluripotent stem cells of scleroderma

Highlights • So far, there have been no reports investigating disease-derived induced pluripotent stem cells (iPSCs) of scleroderma (SSc). We recently generated iPSCs from cultured dermal fibroblasts of SSc (SSc-iPSC) to study disease mechanisms. In the present study, we have performed gene expressi...

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Veröffentlicht in:	Journal of dermatological science 2016-11, Vol.84 (2), p.186-196
Hauptverfasser:	Wang, Zhongzhi, PhD, Nakamura, Kayo, MD, PhD, Jinnin, Masatoshi, MD, PhD, Kudo, Hideo, MD, PhD, Goto, Mizuki, MD, PhD, Era, Takumi, MD, PhD, Kira, Tomomi, MD, PhD, Nakashima, Taiji, MD, PhD, Fukushima, Satoshi, MD, PhD, Ihn, Hironobu, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Biopsy Calgranulin A - metabolism CD18 Antigens - metabolism Cell Differentiation Collagen - metabolism Dermatology Fibroblasts - metabolism Gene Expression Profiling Humans Induced pluripotent stem cells Induced Pluripotent Stem Cells - cytology Mice Middle Aged Phenotype Polymerase Chain Reaction Scleroderma, Systemic - genetics Scleroderma, Systemic - metabolism Sequence Analysis, RNA Skin - metabolism Skin - pathology Smad6 Protein - metabolism Systemic sclerosis Teratoma - metabolism Transforming Growth Factor beta2 - metabolism
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Zusammenfassung:	Highlights • So far, there have been no reports investigating disease-derived induced pluripotent stem cells (iPSCs) of scleroderma (SSc). We recently generated iPSCs from cultured dermal fibroblasts of SSc (SSc-iPSC) to study disease mechanisms. In the present study, we have performed gene expression analysis using cultured SSc dermal fibroblasts, SSc-iPSCs, and fibroblasts re-differentiated from SSc-iPSCs.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2016.08.002