Activity of pyrrolizidine alkaloids against biofilm formation and Trichomonas vaginalis

Graphical abstract Our results point out the applicability of PAs for semi-synthesis as well as indicate these molecules as promising leads for further studies in research for trichomoniasis drugs as well in the development of new antibiofilm strategies.

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2016-10, Vol.83, p.323-329
Hauptverfasser:	da Silva Negreiros Neto, Themístocles, Gardner, Dale, Hallwass, Fernando, Leite, Ana Jéssica Matias, de Almeida, Camila Guimarães, Silva, Laura Nunes, de Araújo Roque, Alan, de Bitencourt, Fernanda Gobbi, Barbosa, Euzébio Guimarães, Tasca, Tiana, Macedo, Alexandre José, de Almeida, Mauro Vieira, Giordani, Raquel Brandt
Format:	Artikel
Sprache:	eng
Schlagworte:	antibacterial properties bacteria biofilm Biofilms - drug effects Biological activity Carbon-13 Magnetic Resonance Spectroscopy Cell Line Crotalaria retusa cytotoxicity epithelial cells Female gas chromatography-mass spectrometry hemolysis Humans Internal Medicine Medical Education Microbial Viability - drug effects Monocrotaline Monocrotaline - chemical synthesis Monocrotaline - chemistry Monocrotaline - isolation & purification Monocrotaline - pharmacology new drugs nuclear magnetic resonance spectroscopy parasites Proton Magnetic Resonance Spectroscopy prototypes Pseudomonas aeruginosa Pyrrolizidine alkaloids Pyrrolizidine Alkaloids - chemistry Pyrrolizidine Alkaloids - isolation & purification Pyrrolizidine Alkaloids - pharmacology retronecine seeds Staphylococcus epidermidis Staphylococcus epidermidis - drug effects Staphylococcus epidermidis - ultrastructure subtropics Trichomonas vaginalis Trichomonas vaginalis - drug effects Trichomonas vaginalis - physiology tropics Usaramine
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Beschreibung
Zusammenfassung:	Graphical abstract Our results point out the applicability of PAs for semi-synthesis as well as indicate these molecules as promising leads for further studies in research for trichomoniasis drugs as well in the development of new antibiofilm strategies.
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2016.06.033