The role of microRNA in periodontal tissue: A review of the literature

Highlights • Bone remodeling and inflammatory mediators orchestrate periodontal tissue pathogenesis. • MicroRNAs modulate RANKL and inflammatory mediator in periodontal resident cells such as gingival fibroblast and periodontal ligament cells. • MicroRNA profiling on diseased periodontal tissue demo...

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Veröffentlicht in:	Archives of oral biology 2016-12, Vol.72, p.66-74
Hauptverfasser:	Irwandi, Rizky Aditiya, Vacharaksa, Anjalee
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Alveolar Bone Loss - genetics Alveolar Bone Loss - physiopathology Biomarkers - metabolism Bone remodeling Bone Remodeling - genetics Bone Remodeling - physiology Dentistry Humans Inflammation Mediators - metabolism Inflammatory mediators MicroRNA MicroRNAs - physiology Osteoprotegerin - metabolism Periodontal Diseases - genetics Periodontal Diseases - physiopathology Periodontal tissue RANK Ligand - metabolism RANKL Receptor Activator of Nuclear Factor-kappa B - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Bone remodeling and inflammatory mediators orchestrate periodontal tissue pathogenesis. • MicroRNAs modulate RANKL and inflammatory mediator in periodontal resident cells such as gingival fibroblast and periodontal ligament cells. • MicroRNA profiling on diseased periodontal tissue demonstrates consistent identification of miR-223 indicating its potency to be further investigated in periodontitis-related processes.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2016.08.014