Expression of microRNA-129-2-3p and microRNA-935 in plasma and brain tissue of human refractory epilepsy
Highlights • 1 GeneChip was used to screen the differentially expressed miRNAs. • 2 RT-qPCR was used to verify the results of microarray. • 3 ROC curve was performed to evaluate the sensitivity and specificity. • 4 miR-129-2-3p was upregulated in patients with refractory epilepsy. • 5 Plasma miR-129...
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| Veröffentlicht in: | Epilepsy research 2016-11, Vol.127, p.276-283 |
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| container_title | Epilepsy research |
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| creator | Sun, Yuqiang Wang, Xiaofeng Wang, Zeyang Zhang, Yuanyang Che, Ningwei Luo, Xiadong Tan, Zeshi Sun, Xu Li, Xinyu Yang, Kang Wang, Guanyu Luan, Lan Liu, Yaoling Zheng, Xiao Wei, Minghai Cheng, Huakun Yin, Jian |
| description | Highlights • 1 GeneChip was used to screen the differentially expressed miRNAs. • 2 RT-qPCR was used to verify the results of microarray. • 3 ROC curve was performed to evaluate the sensitivity and specificity. • 4 miR-129-2-3p was upregulated in patients with refractory epilepsy. • 5 Plasma miR-129-2-3p has great potential as a clinically useful biomarker. |
| doi_str_mv | 10.1016/j.eplepsyres.2016.09.016 |
| format | Article |
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| subjects | Adult Aged Area Under Curve Biomarker Biomarkers - blood Case-Control Studies Cerebral Cortex - metabolism Cerebral Cortex - pathology Cerebral Cortex - surgery Drug Resistant Epilepsy - metabolism Drug Resistant Epilepsy - pathology Drug Resistant Epilepsy - surgery Epilepsy, Temporal Lobe - metabolism Epilepsy, Temporal Lobe - pathology Epilepsy, Temporal Lobe - surgery Female Humans Male Microarray Analysis MicroRNA MicroRNAs - metabolism Middle Aged Neurology Plasma Real-Time Polymerase Chain Reaction Refractory epilepsy ROC Curve Up-Regulation |
| title | Expression of microRNA-129-2-3p and microRNA-935 in plasma and brain tissue of human refractory epilepsy |
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