Expression of microRNA-129-2-3p and microRNA-935 in plasma and brain tissue of human refractory epilepsy

Expression of microRNA-129-2-3p and microRNA-935 in plasma and brain tissue of human refractory epilepsy

Highlights • 1 GeneChip was used to screen the differentially expressed miRNAs. • 2 RT-qPCR was used to verify the results of microarray. • 3 ROC curve was performed to evaluate the sensitivity and specificity. • 4 miR-129-2-3p was upregulated in patients with refractory epilepsy. • 5 Plasma miR-129...

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Veröffentlicht in:Epilepsy research 2016-11, Vol.127, p.276-283
Hauptverfasser: Sun, Yuqiang, Wang, Xiaofeng, Wang, Zeyang, Zhang, Yuanyang, Che, Ningwei, Luo, Xiadong, Tan, Zeshi, Sun, Xu, Li, Xinyu, Yang, Kang, Wang, Guanyu, Luan, Lan, Liu, Yaoling, Zheng, Xiao, Wei, Minghai, Cheng, Huakun, Yin, Jian
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Area Under Curve
Biomarker
Biomarkers - blood
Case-Control Studies
Cerebral Cortex - metabolism
Cerebral Cortex - pathology
Cerebral Cortex - surgery
Drug Resistant Epilepsy - metabolism
Drug Resistant Epilepsy - pathology
Drug Resistant Epilepsy - surgery
Epilepsy, Temporal Lobe - metabolism
Epilepsy, Temporal Lobe - pathology
Epilepsy, Temporal Lobe - surgery
Female
Humans
Male
Microarray Analysis
MicroRNA
MicroRNAs - metabolism
Middle Aged
Neurology
Plasma
Real-Time Polymerase Chain Reaction
Refractory epilepsy
ROC Curve
Up-Regulation
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Zusammenfassung:Highlights • 1 GeneChip was used to screen the differentially expressed miRNAs. • 2 RT-qPCR was used to verify the results of microarray. • 3 ROC curve was performed to evaluate the sensitivity and specificity. • 4 miR-129-2-3p was upregulated in patients with refractory epilepsy. • 5 Plasma miR-129-2-3p has great potential as a clinically useful biomarker.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2016.09.016