The pathophysiology of cardiac dysfunction in epilepsy

The pathophysiology of cardiac dysfunction in epilepsy

Highlights • Dysfunction in cardiac electrophysiology is an established consequence of chronic epilepsy. • Cardiac ion channel expression is believed to be secondarily altered as a result of seizure activity. • Cardiac arrhythmia development may predispose to SUDEP. • Here, we discuss the role of th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Epilepsy research 2016-11, Vol.127, p.19-29
Hauptverfasser: Ravindran, Krishnan, Powell, Kim L, Todaro, Marian, O’Brien, Terence J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Arrhythmia
Cardiac channelopathy
Epilepsy
Epilepsy - physiopathology
Heart Diseases - physiopathology
Humans
Long QT syndrome
Neurology
SUDEP
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Highlights • Dysfunction in cardiac electrophysiology is an established consequence of chronic epilepsy. • Cardiac ion channel expression is believed to be secondarily altered as a result of seizure activity. • Cardiac arrhythmia development may predispose to SUDEP. • Here, we discuss the role of the autonomic nervous system, as well as key ion channels expressed both in the brain and heart that may underlie this phenomenon
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2016.08.007