Glutamate Promotes Contraction of the Rat Ductus Arteriosus

Background:Extremely preterm infants frequently have patent ductus arteriosus (PDA). Recent recommendations include immediately beginning amino acid supplementation in extremely preterm infants. However, the effect of amino acids on closure of the ductus arteriosus (DA) remains unknown.Methods and R...

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Veröffentlicht in:	Circulation Journal 2016/10/25, Vol.80(11), pp.2388-2396
Hauptverfasser:	Fujita, Shujiro, Yokoyama, Utako, Ishiwata, Ryo, Aoki, Rika, Nagao, Kenji, Masukawa, Daiki, Umemura, Masanari, Fujita, Takayuki, Iwasaki, Shiho, Nishimaki, Shigeru, Seki, Kazuo, Ito, Shuichi, Goshima, Yoshio, Asou, Toshihide, Masuda, Munetaka, Ishikawa, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autonomic nerve Ductus Arteriosus - physiology Glutamate Glutamic Acid - pharmacology Humans Infant, Newborn Myocardial Contraction - drug effects Noradrenaline Norepinephrine - biosynthesis Patent ductus arteriosus Preterm infants Rats Rats, Wistar Receptors, AMPA - metabolism
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Zusammenfassung:	Background:Extremely preterm infants frequently have patent ductus arteriosus (PDA). Recent recommendations include immediately beginning amino acid supplementation in extremely preterm infants. However, the effect of amino acids on closure of the ductus arteriosus (DA) remains unknown.Methods and Results:Aminogram results in human neonates at day 2 revealed that the plasma glutamate concentration was significantly lower in extremely preterm infants (
ISSN:	1346-9843 1347-4820
DOI:	10.1253/circj.CJ-16-0649