Repetitive Transcranial Magnetic Stimulation for Treatment Resistant Depression: Re-establishing connections

Highlights • Depression is associated with significant abnormalities in functional and structural connectivity. • rTMS for treatment resistant depression modulates connectivity, normalising pre-treatment abnormalities. • Connectivity imaging can be used to optimise rTMS targeting, explore and predic...

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Veröffentlicht in:	Clinical neurophysiology 2016-11, Vol.127 (11), p.3394-3405
Hauptverfasser:	Anderson, Rodney J, Hoy, Kate E, Daskalakis, Zafiris J, Fitzgerald, Paul B
Format:	Artikel
Sprache:	eng
Schlagworte:	Depressive Disorder, Treatment-Resistant - diagnosis Depressive Disorder, Treatment-Resistant - physiopathology Depressive Disorder, Treatment-Resistant - therapy Functional connectivity Humans Mechanisms of action Nerve Net - physiopathology Neurology Predicting response Prefrontal Cortex - physiopathology Structural connectivity Transcranial magnetic stimulation Transcranial Magnetic Stimulation - methods Transcranial Magnetic Stimulation - trends Treatment Outcome Treatment resistant depression
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Beschreibung
Zusammenfassung:	Highlights • Depression is associated with significant abnormalities in functional and structural connectivity. • rTMS for treatment resistant depression modulates connectivity, normalising pre-treatment abnormalities. • Connectivity imaging can be used to optimise rTMS targeting, explore and predict treatment response.
ISSN:	1388-2457 1872-8952
DOI:	10.1016/j.clinph.2016.08.015