The isoflavone fraction from soybean presents mRNA maturation inhibition activity

The isoflavone fraction from soybean presents mRNA maturation inhibition activity

Recent findings indicate that mRNA splicing inhibitors can be potential anticancer candidates. We have previously established a screening system which monitors mRNA processing in order to identify mRNA processing inhibitors. Among a number of dietary resources, isoflavone fractions showed an inhibit...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2017-03, Vol.81 (3), p.551-554
Hauptverfasser: Kurata, Masashi, Murata, Yuki, Momma, Keiko, Fouad Ali Mursi, Intisar, Takahashi, Masakazu, Miyamae, Yusaku, Kambe, Taiho, Nagao, Masaya, Narita, Hiroshi, Shibuya, Yasuyuki, Masuda, Seiji
Format: Artikel
Sprache:eng
Schlagworte:
Cell Line
Drug Evaluation, Preclinical - methods
Glycine max - chemistry
HeLa Cells - drug effects
Humans
In Situ Hybridization, Fluorescence
Isoflavones - pharmacology
luciferase
Luciferases, Renilla - genetics
RNA Processing, Post-Transcriptional
RNA Splicing
RNA, Messenger - metabolism
RNA-FISH
Soyaflavone HG
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Zusammenfassung:Recent findings indicate that mRNA splicing inhibitors can be potential anticancer candidates. We have previously established a screening system which monitors mRNA processing in order to identify mRNA processing inhibitors. Among a number of dietary resources, isoflavone fractions showed an inhibitory effect of mRNA processing. These findings demonstrate that a variety of dietary sources have an impact on mRNA biogenesis.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2016.1249451