Role of Statins in Delirium Prevention in Critical Ill and Cardiac Surgery Patients: A Systematic Review and Meta-Analysis

Abstract Background The data evaluating the role of statins in delirium prevention in the intensive care unit (ICU) is conflicting and limited. Methods We performed a systematic review and meta-analysis of literature from 1975 to 2015. All English language adult studies evaluating delirium incidence...

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Veröffentlicht in:	Journal of critical care 2017-02, Vol.37, p.189-196
Hauptverfasser:	Vallabhajosyula, Saraschandra, MBBS, Kanmanthareddy, Arun, MD, MS, Erwin, Patricia J, MLS, Esterbrooks, Dennis J, MD, FACC, Morrow, Lee E, MD, MSc, FACP, FCCP
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiac surgery Cardiac Surgical Procedures Cardiovascular disease Consciousness Coronary vessels Critical Care Critical Illness Delirium Delirium - prevention & control Heart surgery Hospitals Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Intensive Care Units Meta-analysis Mortality Neurosciences Patients Postoperative Complications - prevention & control Statins Statistical analysis Studies Ventilation
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Zusammenfassung:	Abstract Background The data evaluating the role of statins in delirium prevention in the intensive care unit (ICU) is conflicting and limited. Methods We performed a systematic review and meta-analysis of literature from 1975 to 2015. All English language adult studies evaluating delirium incidence in statin and statin non-users were included and studies without a control group were excluded. Mantel–Haenszel model was used to calculate pooled risk ratios (RR) and 95% confidence intervals (CI). Statistical significance was defined as CI not including unity and p -value
ISSN:	0883-9441 1557-8615
DOI:	10.1016/j.jcrc.2016.09.025