Antigen Presentation to B Cells
Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of rec...
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| Veröffentlicht in: | Trends in immunology 2016-12, Vol.37 (12), p.844-854 |
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| container_issue | 12 |
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| container_title | Trends in immunology |
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| creator | Heesters, Balthasar A van der Poel, Cees E Das, Abhishek Carroll, Michael C |
| description | Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors. While B cells can interact with soluble antigens, it is now clear that the presentation of membrane-bound antigen plays a crucial role in B cell activation, and in particular during affinity-maturation, the process during which high-affinity B cells are selected. In this review we discuss how native antigen is presented to B cells and its impact at several stages of B cell responses. |
| doi_str_mv | 10.1016/j.it.2016.10.003 |
| format | Article |
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The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors. While B cells can interact with soluble antigens, it is now clear that the presentation of membrane-bound antigen plays a crucial role in B cell activation, and in particular during affinity-maturation, the process during which high-affinity B cells are selected. 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| ispartof | Trends in immunology, 2016-12, Vol.37 (12), p.844-854 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Allergy and Immunology Animals Antibody Affinity Antigen Presentation Antigen-Presenting Cells - immunology Antigens - immunology B-Lymphocytes - immunology Clonal Selection, Antigen-Mediated Complement Activation Dendritic cells Humans Lymphocyte Activation Lymphocyte receptors Phagocytosis Receptors, Antigen, B-Cell - metabolism Streptococcus infections T cell receptors |
| title | Antigen Presentation to B Cells |
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