Antigen Presentation to B Cells

Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of rec...

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Veröffentlicht in:Trends in immunology 2016-12, Vol.37 (12), p.844-854
Hauptverfasser: Heesters, Balthasar A, van der Poel, Cees E, Das, Abhishek, Carroll, Michael C
Format: Artikel
Sprache:eng
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Zusammenfassung:Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors. While B cells can interact with soluble antigens, it is now clear that the presentation of membrane-bound antigen plays a crucial role in B cell activation, and in particular during affinity-maturation, the process during which high-affinity B cells are selected. In this review we discuss how native antigen is presented to B cells and its impact at several stages of B cell responses.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2016.10.003