Two-step three-component process for one-pot synthesis of 8-alkylmercaptocaffeine derivatives

A highly efficient, odourless and two-step three-component process for one-pot synthesis of some 8-alkylmercaptocaffeine derivatives has been described. The catalyst-free three-component reaction of alkyl bromides, thiourea, and 8-bromocaffeine gave 8-alkylmercaptocaffeine products in excellent to quantitative yields. In addition, the impact of parameters on sample reaction is discussed. A two-step three-component process for one-pot synthesis of some 8-alkylmercaptocaffeine derivatives has been described using alkyl bromides, thiourea, and 8-bromocaffeine.