Molecularly imprinted polymer-based bulk optode for the determination of itopride hydrochloride in physiological fluids

We report here for the first time on the use of Molecularly Imprinted Polymers as modifiers in bulk optodes, Miptode, for the determination of a pharmaceutical compound, itopride hydrochloride as an example in a concentration range of 1×10−1–1×10−4molL−1. In comparison to the optode containing the ion exchanger only (Miptode 3), the optode containing the ion exchanger and the MIP particles (Miptode 2) showed improved selectivity over the most lipophilic species, Na+ and K+, by more than two orders of magnitude. For instance, the optical selectivity coefficients using Miptode 2, logKIP,J+=opt, were as follow: NH4+˂−6; Na+=−4.0, which were greatly enhanced in comparison with that obtained by Miptode 3. This work opens a new avenue for using miptodes for the determination of all the pharmaceutical preparations without the need for the development of new ionophores. •Molecularly Imprinted Polymers was used as modifiers in bulk optodes, Miptode.•Miptode response was fully optimized.•Miptode was applied successfully to the analysis of itopride in urine samples.