Preparation of Well-Defined DNA Samples for Reproducible Nanospectroscopic Measurements

Preparation of Well-Defined DNA Samples for Reproducible Nanospectroscopic Measurements

Due to its well‐defined topology and chemical structure, DNA could become a biological standard sample in the field of nanospectroscopy. Tip‐enhanced Raman spectroscopy (TERS) provides new insights into individual DNA molecules immobilized on flat mica crystals. The high sensitivity of TERS is used...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2016-09, Vol.12 (35), p.4821-4829
Hauptverfasser: Lipiec, Ewelina, Japaridze, Aleksandre, Szczerbiński, Jacek, Dietler, Giovanni, Zenobi, Renato
Format: Artikel
Sprache:eng
Schlagworte:
Aluminum Silicates - chemistry
Crystals
Deoxyribonucleic acid
DNA
DNA - chemistry
DNA conformation
Genetic testing
Immobilization
Mica
Microscopy, Atomic Force
nanospectroscopy
Nanostructure
Nanostructures - chemistry
Nanotechnology
Principal Component Analysis
Propylamines - chemistry
Raman spectroscopy
Reproducibility of Results
Silanes - chemistry
Spectrum Analysis, Raman
TERS
TERS, nanospectroscopy
Topology
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Beschreibung
Zusammenfassung:Due to its well‐defined topology and chemical structure, DNA could become a biological standard sample in the field of nanospectroscopy. Tip‐enhanced Raman spectroscopy (TERS) provides new insights into individual DNA molecules immobilized on flat mica crystals. The high sensitivity of TERS is used to assess the chemical changes that appear in DNA upon different surface immobilization protocols.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201601711