Graphene/Nafion composite film modified glassy carbon electrode for simultaneous determination of paracetamol, aspirin and caffeine in pharmaceutical formulations

A graphene-Nafion composite film was fabricated on the glassy carbon electrode (GR-NF/GCE), and used for simultaneous determination of paracetamol (PAR), aspirin (ASA) and caffeine (CAF). The electrochemical behaviors of PAR, ASA and CAF were investigated by cyclic voltammetry and square-wave adsorptive anodic stripping voltammetry. By using stripping one for simultaneous determination of PAR, ASA and CAF, their electrochemical oxidation peaks appeared at +0.64, 1.04 and 1.44V, and good linear current responses were obtained with the detection limits of 18ngmL−1 (1.2×10−9M), 11.7ngmL−1 (6.5×10−8M) and 7.3ngmL−1 (3.8×10−8M), respectively. Finally, the proposed electrochemical sensor was successfully applied for quantifying PAR, ASA and CAF in commercial tablet formulations. [Display omitted] •A graphene/Nafion composite film modified glassy carbon electrode was fabricated and characterized.•The modified electrode was introduced for the simultaneous determination of PAR, ASA and CAF.•The sensor exhibited high sensitivity, excellent reproducibility and good stability.•The application was conducted for commercial tablet samples.