Drug interaction between erlotinib and phenytoin for brain metastases in a patient with nonsmall cell lung cancer

Highlights • The phenytoin blood concentration increased by erlotinib co-administration. • The erlotinib blood concentration increased after the stoppage of phenytoin. • It is important to avoid enzyme-inducing antiepileptic drugs when erlotinib is used.

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Bibliographische Detailangaben
Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-11, Vol.101, p.9-10
Hauptverfasser:	Ohgami, Masahiro, Kaburagi, Takayuki, Kurosawa, Atsuhiko, Homma, Masato
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - pathology Brain Neoplasms - complications Brain Neoplasms - drug therapy Brain Neoplasms - secondary Carcinoma, Non-Small-Cell Lung - complications Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Cytochrome P-450 CYP1A2 Inducers - blood Cytochrome P-450 CYP1A2 Inducers - therapeutic use Cytochrome P-450 CYP3A - metabolism Drug Interactions Drug-drug interaction Erlotinib Erlotinib Hydrochloride - blood Erlotinib Hydrochloride - therapeutic use Female Hematology, Oncology and Palliative Medicine Humans Lung Neoplasms - pathology Middle Aged Phenytoin Phenytoin - adverse effects Phenytoin - blood Phenytoin - therapeutic use Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Pulmonary/Respiratory Receptor, Epidermal Growth Factor - antagonists & inhibitors Seizures - drug therapy Seizures - etiology Treatment Outcome
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Beschreibung
Zusammenfassung:	Highlights • The phenytoin blood concentration increased by erlotinib co-administration. • The erlotinib blood concentration increased after the stoppage of phenytoin. • It is important to avoid enzyme-inducing antiepileptic drugs when erlotinib is used.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2016.08.009