Triboelectric Nanogenerator Accelerates Highly Efficient Nonviral Direct Conversion and In Vivo Reprogramming of Fibroblasts to Functional Neuronal Cells

Triboelectric nanogenerators (TENGs) can be an effective cell reprogramming platform for producing functional neuronal cells for therapeutic applications. Triboelectric stimulation accelerates nonviral direct conversion of functional induced neuronal cells from fibroblasts, increases the conversion...

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Veröffentlicht in:	Advanced materials (Weinheim) 2016-09, Vol.28 (34), p.7365-7374
Hauptverfasser:	Jin, Yoonhee, Seo, Jungmok, Lee, Jung Seung, Shin, Sera, Park, Hyun-Ji, Min, Sungjin, Cheong, Eunji, Lee, Taeyoon, Cho, Seung-Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical materials Conversion Direct conversion Fibroblasts in vivo reprogramming induced neuronal cells Medical devices Nanostructure neuronal maturation nonviral direct conversion Platforms Stimulation triboelectric nanogenerators
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Beschreibung
Zusammenfassung:	Triboelectric nanogenerators (TENGs) can be an effective cell reprogramming platform for producing functional neuronal cells for therapeutic applications. Triboelectric stimulation accelerates nonviral direct conversion of functional induced neuronal cells from fibroblasts, increases the conversion efficiency, and induces highly matured neuronal phenotypes with improved electrophysiological functionalities. TENG devices may also be used for biomedical in vivo reprogramming.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201601900