Enantioselective Copper-Catalyzed Intramolecular N−H Bond Insertion: Synthesis of Chiral 2-Carboxytetrahydroquinolines

Enantioselective Copper-Catalyzed Intramolecular N−H Bond Insertion: Synthesis of Chiral 2-Carboxytetrahydroquinolines

The first highly enantioselective intramolecular N−H bond insertion was realized by using copper catalysts modified with chiral spirobisoxazoline ligands, which provides a novel strategy for the synthesis of chiral 2‐carboxytetrahydroquinolines. This reaction features fast reaction rate, high yield,...

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Veröffentlicht in:Advanced synthesis & catalysis 2016-07, Vol.358 (15), p.2366-2370
Hauptverfasser: Song, Xiao-Guang, Ren, Yuan-Yuan, Zhu, Shou-Fei, Zhou, Qi-Lin
Format: Artikel
Sprache:eng
Schlagworte:
2-carboxytetrahydroquinolines
asymmetric catalysis
Bonding
carbene insertion
Catalysis
Catalysts
chiral spiro ligands
Copper
Insertion
Ligands
Strategy
Synthesis
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Zusammenfassung:The first highly enantioselective intramolecular N−H bond insertion was realized by using copper catalysts modified with chiral spirobisoxazoline ligands, which provides a novel strategy for the synthesis of chiral 2‐carboxytetrahydroquinolines. This reaction features fast reaction rate, high yield, high enantioselectivity, and mild reaction conditions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201600390