Replication of α-amino acids via Strecker synthesis with amplification and multiplication of chiral intermediate aminonitriles

Replication of α-amino acids via Strecker synthesis with amplification and multiplication of chiral intermediate aminonitriles

Replication of chiral l- and d-α-(p-tolyl)glycine has been achieved in combination with the asymmetric induction, amplification and multiplication of their own chiral intermediates, l- and d-aminonitriles, in the solid-phase via the Strecker reaction between three achiral components, which is a plau...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (72), p.10834-10837
Hauptverfasser: Aiba, Shohei, Takamatsu, Naoya, Sasai, Taichiro, Tokunaga, Yuji, Kawasaki, Tsuneomi
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Amino Acids - chemistry
Amplification
Asymmetry
Glycine - chemistry
Multiplication
Nitriles - chemical synthesis
Nitriles - chemistry
Replication
Solid-Phase Synthesis Techniques
Stereoisomerism
Synthesis
Synthesis (chemistry)
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Beschreibung
Zusammenfassung:Replication of chiral l- and d-α-(p-tolyl)glycine has been achieved in combination with the asymmetric induction, amplification and multiplication of their own chiral intermediates, l- and d-aminonitriles, in the solid-phase via the Strecker reaction between three achiral components, which is a plausible prebiotic mechanism for amino acid synthesis.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc05544c