A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo

A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo

A novel near-infrared (NIR), turn-on fluorescence probe containing a phosphinate group as a recognizing moiety for the selective detection of O2˙(-) with a low limit of detection (LOD, 9.9 nM) was developed. has good cell-membrane permeability, intracellular stability, and low cytotoxicity. In addit...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (13), p.2679-2682
Hauptverfasser: Zhang, Jianjian, Li, Chuwen, Zhang, Rui, Zhang, Fengyuan, Liu, Wei, Liu, Xiaoyan, Lee, Simon Ming-Yuen, Zhang, Haixia
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anions
Fluorescence
Fluorescent Dyes - chemistry
Hep G2 Cells
Humans
Imaging
In Vitro Techniques
Infrared Rays
Limit of Detection
Liver
Mice
Permeability
Phosphinic Acids - chemistry
Radicals
Stability
Superoxides - analysis
Zebrafish
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Zusammenfassung:A novel near-infrared (NIR), turn-on fluorescence probe containing a phosphinate group as a recognizing moiety for the selective detection of O2˙(-) with a low limit of detection (LOD, 9.9 nM) was developed. has good cell-membrane permeability, intracellular stability, and low cytotoxicity. In addition, we successfully applied the to visualize O2˙(-) in live zebrafish, mouse and, for the first time, in mouse liver.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc09976e