Protein self-assembly induces promiscuous nucleophilic biocatalysis in Morita–Baylis–Hillman (MBH) reaction

Protein self-assembly induces promiscuous nucleophilic biocatalysis in Morita–Baylis–Hillman (MBH) reaction

Self-assembled states of proteins render efficient promiscuous nucleophilic biocatalysis in MBH reaction in a green process. The His and Arg based catalophores in proteins operate in aqueous buffer at neutral pH and ambient temperature. Steady-state fluorimetric approaches reveal that lower order ag...

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Veröffentlicht in:RSC advances 2016-01, Vol.6 (1), p.208-211
Hauptverfasser: Joshi, Pralhad N., Purushottam, Landa, Das, Nirmal K., Mukherjee, Saptarshi, Rai, Vishal
Format: Artikel
Sprache:eng
Schlagworte:
Aggregates
Ambient temperature
Buffers
Proteins
Self assembly
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Zusammenfassung:Self-assembled states of proteins render efficient promiscuous nucleophilic biocatalysis in MBH reaction in a green process. The His and Arg based catalophores in proteins operate in aqueous buffer at neutral pH and ambient temperature. Steady-state fluorimetric approaches reveal that lower order aggregates play a seminal role in the biocatalytic process.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA23949D