PCI-24781 can improve in vitro and in vivo developmental capacity of pig somatic cell nuclear transfer embryos

Objective To examine the effect of PCI-24781 (abexinostat) on the blastocyst formation rate in pig somatic cell nuclear transferred (SCNT) embryos and acetylation levels of the histone H3 lysine 9 and histone H4 lysine 12. Results Treatment with 0.5 nM PCI-24781 for 6 h significantly improved the de...

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Veröffentlicht in:	Biotechnology letters 2016-09, Vol.38 (9), p.1433-1441
Hauptverfasser:	Jin, Long, Zhu, Hai-Ying, Guo, Qing, Li, Xiao-Chen, Zhang, Yu-Chen, Zhang, Guang-Lei, Xing, Xiao-Xu, Xuan, Mei-Fu, Luo, Qi-Rong, Yin, Xi-Jun, Kang, Jin-Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Applied Microbiology Benzofurans - pharmacology Biochemistry Biomedical and Life Sciences Biotechnology Embryo, Mammalian - drug effects Embryo, Mammalian - metabolism Embryology Embryonic Development - drug effects Embryonic Development - genetics Embryos Enzymes Female Fetuses Formations Histone Deacetylase Inhibitors - pharmacology Histones Hydroxamic Acids - pharmacology Life Sciences Lysine Microbiology Nuclear Transfer Techniques Original Research Paper Pregnancy Swine
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Zusammenfassung:	Objective To examine the effect of PCI-24781 (abexinostat) on the blastocyst formation rate in pig somatic cell nuclear transferred (SCNT) embryos and acetylation levels of the histone H3 lysine 9 and histone H4 lysine 12. Results Treatment with 0.5 nM PCI-24781 for 6 h significantly improved the development of cloned embryos, in comparison to the control group (25.3 vs. 10.5 %, P
ISSN:	0141-5492 1573-6776
DOI:	10.1007/s10529-016-2141-0