Ocfentanil overdose fatality in the recreational drug scene

Highlights • First reported ocfentanil overdose fatality: case history and analytical findings. • New structure analogue of fentanyl abused as a new psychoactive substance (NPS) • Determination of ocfentanil in postmortem samples by UPLC-MS/MS: method validation. • Potent synthetic opioid used as a...

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Veröffentlicht in:	Forensic science international 2016-09, Vol.266, p.469-473
Hauptverfasser:	Vera, Coopman, Jan, Cordonnier, De Leeuw, Marc, Cirimele, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - toxicity Acids Acute intoxication Adolescent Alcohol Analgesics Arrays Autopsies Autopsy Biological properties Biological samples Blood Caffeine Caffeine - toxicity Calibration Chromatography Chromatography, Liquid Cocaine Currencies Death Drug abuse Drug Overdose - diagnosis Drug Overdose - pathology Drugs Fatal Outcome Fatalities Femur Fentanyl Fentanyl analogue Forensic sciences Gas chromatography Heroin Humans Intoxication Investigations Liquid chromatography Male Mass Spectrometry Mass spectroscopy Mortality Narcotics New psychoactive substances (NPS) Ocfentanil Opioids Overdose Particle size Pathology Piperidines - toxicity Postmortem Changes Powder Quantitation Recreational drugs Scientific imaging Sensors Spectroscopy Street Drugs - toxicity Studies Tissue distribution Ultra performance liquid chromatography mass spectrometry (UPLC-MS) Urine
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Beschreibung
Zusammenfassung:	Highlights • First reported ocfentanil overdose fatality: case history and analytical findings. • New structure analogue of fentanyl abused as a new psychoactive substance (NPS) • Determination of ocfentanil in postmortem samples by UPLC-MS/MS: method validation. • Potent synthetic opioid used as a ‘legal’ substitute of morphine and heroin.
ISSN:	0379-0738 1872-6283
DOI:	10.1016/j.forsciint.2016.07.005