Improved Biocompatibility of Novel Biodegradable Scaffold Composed of Poly-L-lactic Acid and Amorphous Calcium Phosphate Nanoparticles in Porcine Coronary Artery

Using poly-L-lactic acid for implantable biodegradable scaffold has potential biocompatibility issue due to its acidic degradation byproducts. We have previously reported that the addition of amorphous calcium phosphate improved poly-L-lactic acid coating biocompatibility. In the present study, poly...

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Veröffentlicht in:Journal of nanomaterials 2016-01, Vol.2016 (2016), p.1-8
Hauptverfasser: Wang, Zhimin, Wang, Qun, Wu, Tim, Jiang, Xuejun, Gu, Weiwang, Xiao, Jianmin, Xia, Jinxi, Fan, Jingyao, Wang, Shihang, Bi, Yuying, Zheng, Xiaoxin, Kang, Guanyang, Feng, Gaoke, Gu, Dongsheng, Huo, Zhicheng
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Sprache:eng
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Zusammenfassung:Using poly-L-lactic acid for implantable biodegradable scaffold has potential biocompatibility issue due to its acidic degradation byproducts. We have previously reported that the addition of amorphous calcium phosphate improved poly-L-lactic acid coating biocompatibility. In the present study, poly-L-lactic acid and poly-L-lactic acid/amorphous calcium phosphate scaffolds were implanted in pig coronary arteries for 28 days. At the follow-up angiographic evaluation, no case of stent thrombosis was observed, and the arteries that were stented with the copolymer scaffold had significantly less inflammation and nuclear factor-κB expression and a greater degree of reendothelialization. The serum levels of vascular endothelial growth factor and nitric oxide, as well the expression of endothelial nitric oxide synthase and platelet-endothelial cell adhesion molecule-1, were also significantly higher. In conclusion, the addition of amorphous calcium phosphate to biodegradable poly-L-lactic acid scaffold minimizes the inflammatory response, promotes the growth of endothelial cells, and accelerates the reendothelialization of the stented coronary arteries.
ISSN:1687-4110
1687-4129
DOI:10.1155/2016/2710858