An external portable device for adaptive deep brain stimulation (aDBS) clinical research in advanced Parkinson's Disease

Highlights • DBS limitations in treating PD patients might be overcome by closed-loop devices implementing adaptive stimulation protocols. • We developed an external portable aDBS system prototype aimed to promote clinical investigations in Parkinson's Disease. • We validated the aDBS system pr...

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Veröffentlicht in:	Medical engineering & physics 2016-05, Vol.38 (5), p.498-505
Hauptverfasser:	Arlotti, Mattia, Rossi, Lorenzo, Rosa, Manuela, Marceglia, Sara, Priori, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive deep brain stimulation Brain Closed loop stimulation DBS Deep Brain Stimulation - instrumentation Electrophysiological Phenomena - drug effects Equipment Design Feedback Humans Levodopa - pharmacology Local field potentials Parameters Parkinson Disease - physiopathology Parkinson Disease - therapy Parkinson's Disease Patients Prototypes Radiology Stimulation Time Factors Tuning
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Zusammenfassung:	Highlights • DBS limitations in treating PD patients might be overcome by closed-loop devices implementing adaptive stimulation protocols. • We developed an external portable aDBS system prototype aimed to promote clinical investigations in Parkinson's Disease. • We validated the aDBS system prototype. • The aDBS system prototype successfully tracked the power changes induced by medication and stimulation by means of a real-time spectral analysis.
ISSN:	1350-4533 1873-4030
DOI:	10.1016/j.medengphy.2016.02.007