Effects of Genetic and Nongenetic Factors on Total and Bioavailable 25(OH)D Responses to Vitamin D Supplementation

Précis: We conducted a 20-week trial and found 2000 IU/d vitamin D3 raised 25(OH)D and 25(OH)DBio, but the uncorrected deficiency remained high, which might be partially attributed to genetic factor effect.  Abstract Context: Little is known about how genetic and nongenetic factors modify responses...

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Veröffentlicht in:The journal of clinical endocrinology and metabolism 2017-01, Vol.102 (1), p.100-110
Hauptverfasser: Yao, Pang, Sun, Liang, Lu, Ling, Ding, Hong, Chen, Xiafei, Tang, Lixin, Xu, Xinming, Liu, Gang, Hu, Yao, Ma, Yiwei, Wang, Feijie, Jin, Qianlu, Zheng, He, Yin, Huiyong, Zeng, Rong, Chen, Yan, Hu, Frank B., Li, Huaixing, Lin, Xu
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Sprache:eng
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Zusammenfassung:Précis: We conducted a 20-week trial and found 2000 IU/d vitamin D3 raised 25(OH)D and 25(OH)DBio, but the uncorrected deficiency remained high, which might be partially attributed to genetic factor effect.  Abstract Context: Little is known about how genetic and nongenetic factors modify responses of vitamin D supplementation in nonwhite populations. Objective: To investigate factors modifying 25-hydroxyvitamin D [25(OH)D] and bioavailable 25(OH)D [25(OH)DBio] responses after vitamin D3 supplementation. Design, Setting, Participants, and Intervention: In this 20-week, randomized, double-blinded, placebo-controlled trial, 448 Chinese with vitamin D deficiency received 2000 IU/d vitamin D3 or placebo. Main Outcome Measures: Serum 25(OH)D, vitamin D-binding protein (VDBP), parathyroid hormone (PTH) and calcium were measured, and 25(OH)DBio was calculated based on VDBP levels. Six common polymorphisms in vitamin D metabolism genes were genotyped. Results: Between-arm net changes were +30.6 ± 1.7 nmol/L for 25(OH)D, +2.7 ± 0.2 nmol/L for 25(OH)DBio, and −5.2 ± 1.2 pg/mL for PTH, corresponding to 70% [95% confidence interval (CI), 62.8% to 77.2%] net reversion rate for vitamin D deficiency at week 20 (P < 0.001). Only 25(OH)DBio change was positively associated with calcium change (P < 0.001). Genetic factors (GC-rs4588/GC-rs7041, VDR-rs2228570, and CYP2R1-rs10741657; P ≤ 0.04) showed stronger influences on 25(OH)D or 25(OH)DBio responses than nongenetic factors, including baseline value, body mass index, and sex. An inverse association of PTH-25(OH)D was demonstrated only at 25(OH)D of
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2016-2930