Simultaneous noninvasive recording of skin sympathetic nerve activity and electrocardiogram

Background Sympathetic nerve activity is important to cardiac arrhythmogenesis. Objective The purpose of this study was to develop a method for simultaneous noninvasive recording of skin sympathetic nerve activity (SKNA) and electrocardiogram (ECG) using conventional ECG electrodes. This method (neu...

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Veröffentlicht in:	Heart rhythm 2017-01, Vol.14 (1), p.25-33
Hauptverfasser:	Doytchinova, Anisiia, MD, Hassel, Jonathan L., MD, Yuan, Yuan, MD, Lin, Hongbo, MS, Yin, Dechun, MD, Adams, David, BSEE, Straka, Susan, RN, Wright, Keith, BS, Smith, Kimberly, BA, Wagner, David, BSEE, Shen, Changyu, PhD, Salanova, Vicenta, MD, Meshberger, Chad, DO, Chen, Lan S., MD, Kincaid, John C., MD, Coffey, Arthur C., MD, Wu, Gang, MD, Li, Yan, MD, PhD, Kovacs, Richard J., MD, Everett, Thomas H., PhD, FHRS, Victor, Ronald, MD, Cha, Yong-Mei, MD, FHRS, Lin, Shien-Fong, PhD, FHRS, Chen, Peng-Sheng, MD, FHRS
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Cardiovascular Case-Control Studies Cold water pressor test Electrocardiography - instrumentation Electrocardiography - methods Electrodes Female Heart Rate - physiology Humans Male Microneurography Middle Aged Reference Values Skin - innervation Stellate Ganglion - physiopathology Sympathetic nerve activity Sympathetic Nervous System - physiology Tachycardia, Ventricular - diagnosis Ventricular tachycardia
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Zusammenfassung:	Background Sympathetic nerve activity is important to cardiac arrhythmogenesis. Objective The purpose of this study was to develop a method for simultaneous noninvasive recording of skin sympathetic nerve activity (SKNA) and electrocardiogram (ECG) using conventional ECG electrodes. This method (neuECG) can be used to adequately estimate sympathetic tone. Methods We recorded neuECG signals from the skin of 56 human subjects. The signals were low-pass filtered to show the ECG and high-pass filtered to show nerve activity. Protocol 1 included 12 healthy volunteers who underwent cold water pressor test and Valsalva maneuver. Protocol 2 included 19 inpatients with epilepsy but without known heart diseases monitored for 24 hours. Protocol 3 included 22 patients admitted with electrical storm and monitored for 39.0 ± 28.2 hours. Protocol 4 included 3 patients who underwent bilateral stellate ganglion blockade with lidocaine injection. Results In patients without heart diseases, spontaneous nerve discharges were frequently observed at baseline and were associated with heart rate acceleration. SKNA recorded from chest leads (V1 –V6 ) during cold water pressor test and Valsalva maneuver (protocol 1) was invariably higher than during baseline and recovery periods ( P
ISSN:	1547-5271 1556-3871
DOI:	10.1016/j.hrthm.2016.09.019