Effects of noradrenaline and KCl on peripheral vessels in doxorubicin induced model of heart failure

Effects of noradrenaline and KCl on peripheral vessels in doxorubicin induced model of heart failure

The purpose of the work presented here was to investigate the responses mediated by alpha-adrenoceptors and also contractility of vascular smooth muscle in large peripheral vessels following doxorubicin (DXR)-induced heart failure. Cardiac failure was induced by DXR injection. Thirty saline-treated...

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Veröffentlicht in:Pathophysiology (Amsterdam) 2002-08, Vol.8 (4), p.259-262
Hauptverfasser: Ahmadiasl, N, Rostami, A, Mohammadi, Naghadeh M, Rajabi, F
Format: Artikel
Sprache:eng
Schlagworte:
Doxorubicin
Heart failure
KCl
Noradrenaline
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Zusammenfassung:The purpose of the work presented here was to investigate the responses mediated by alpha-adrenoceptors and also contractility of vascular smooth muscle in large peripheral vessels following doxorubicin (DXR)-induced heart failure. Cardiac failure was induced by DXR injection. Thirty saline-treated (normal group) and 30 DXR-treated rabbits (1 mg/kg administered intravenously twice weekly for 8 weeks) were studied. Chronic heart failure was confirmed by echocardiography and later also by histopathology. The DXR-treated hearts were subdivided by ejection fraction >40 or
ISSN:0928-4680
1873-149X
DOI:10.1016/S0928-4680(02)00012-3