Knockout Corner: Knockout mice for monoamine oxidase A

A line of transgenic mice was isolated in which transgene integration had caused a deletion in the gene encoding monoamine oxidase A, an enzyme that degrades serotonin and norepinephrine. This has provided an animal model of MAOA deficiency in humans, a condition characterized by borderline mental r...

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Veröffentlicht in:The international journal of neuropsychopharmacology 1999-09, Vol.2 (3), p.241-243, Article S1461145799001534
Hauptverfasser: Seif, Isabelle, De Maeyer, Edward
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container_title The international journal of neuropsychopharmacology
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creator Seif, Isabelle
De Maeyer, Edward
description A line of transgenic mice was isolated in which transgene integration had caused a deletion in the gene encoding monoamine oxidase A, an enzyme that degrades serotonin and norepinephrine. This has provided an animal model of MAOA deficiency in humans, a condition characterized by borderline mental retardation and impulsive aggression.
doi_str_mv 10.1017/S1461145799001534
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ispartof The international journal of neuropsychopharmacology, 1999-09, Vol.2 (3), p.241-243, Article S1461145799001534
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source Access via Oxford University Press (Open Access Collection); EZB-FREE-00999 freely available EZB journals
subjects Trends and Perspectives
title Knockout Corner: Knockout mice for monoamine oxidase A
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