The Predictive Value of Tumor Size, Volume, and Markers During Radiation Therapy in Patients With Cervical Cancer

OBJECTIVESWe investigated the prognostic significance of changes in primary tumor volume and serum squamous cell carcinoma antigen (SCC-ag) levels during radiation therapy (RT) in patients with cervical cancer. METHODSWe conducted a review of 40 patients treated with RT. All patients received extern...

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Veröffentlicht in:	International journal of gynecological cancer 2017-01, Vol.27 (1), p.123-130
Hauptverfasser:	Lee, Kyu Chan, Kim, Hun Jung, Sung, KiHoon, Choi, Young Eun, Lee, Seok Ho, Lim, Soyi, Lee, Kwang Beom, Shin, Jin Woo, Park, Chan Yong, Kim, Young Saing, Sym, Sun Jin, Shim, Young Sup, Choi, Seung Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antigens Antigens, Neoplasm - blood Biomarkers, Tumor - blood Brachytherapy Cervical cancer Disease-Free Survival Female Humans Medical prognosis Middle Aged Neoplasm Staging Predictive Value of Tests Prognosis Radiation therapy Retrospective Studies Serpins - blood Squamous cell carcinoma Survival Rate Uterine Cervical Neoplasms - blood Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy
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Zusammenfassung:	OBJECTIVESWe investigated the prognostic significance of changes in primary tumor volume and serum squamous cell carcinoma antigen (SCC-ag) levels during radiation therapy (RT) in patients with cervical cancer. METHODSWe conducted a review of 40 patients treated with RT. All patients received external beam RT and intracavitary brachytherapy. The primary tumor volume and squamous cell carcinoma antigen levels were measured pre-RT and mid-RT. Overall survival (OS) and progression free survival (PFS) were estimated, and possible prognostic factors for survival were analyzed. RESULTSThe correlation coefficient between primary tumor volume reduction rate (pTVRR) and serum squamous cell carcinoma antigen reduction rate in all patients was 0.550 (P < 0.001). In univariate analysis, stage more than II (P
ISSN:	1048-891X 1525-1438
DOI:	10.1097/IGC.0000000000000837