Limitations of the Anticholinergic Activity Assay and Assay-Based Anticholinergic Drug Scales

Objective The anticholinergic activity (AA) assay is a common method to determine a patient's anticholinergic load. Several limitations, however, are expected when applying the AA assay to patients or using drug scales to estimate anticholinergic burden based on AA levels. This study aims to de...

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Veröffentlicht in:	The American journal of geriatric psychiatry 2016-12, Vol.24 (12), p.1182-1188
Hauptverfasser:	Mayer, Tanja, pharmacist, Kopitz, Jürgen, Ph.D, Plaschke, Konstanze, Dr.Sc.Hum, Weiss, Johanna, Ph.D, Seidling, Hanna M., Dr.Sc.Hum, Haefeli, Walter E., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amitriptyline - adverse effects Amitriptyline - blood Amitriptyline - therapeutic use anticholinergic activity anticholinergic load Anticholinergics antimuscarinic drugs Bioassays Cholinergic Antagonists - adverse effects Cholinergic Antagonists - blood Cholinergic Antagonists - therapeutic use Cognitive Dysfunction - chemically induced Cognitive Dysfunction - prevention & control Dementia Diphenhydramine - blood Dose-Response Relationship, Drug Drug Interactions Drugs Furosemide - adverse effects Furosemide - blood Furosemide - therapeutic use Humans Internal Medicine Metabolites Nortriptyline - blood Pilocarpine - blood Radioisotopes Radioligand Assay receptor-binding assay Research methodology Thioridazine - blood
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