Heterogeneity of Rotavirus Vaccine Efficacy Among Infants in Developing Countries

BACKGROUND:Rotavirus is the leading cause of severe diarrhea worldwide in young children. Although rotavirus vaccine efficacy is high in developed countries, efficacy is lower in developing countries. Here, we investigated heterogeneity of rotavirus vaccine efficacy by infant characteristics in deve...

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Veröffentlicht in:The Pediatric infectious disease journal 2017-01, Vol.36 (1), p.72-78
Hauptverfasser: Gruber, Joann F, Hille, Darcy A, Liu, G Frank, Kaplan, Susan S, Nelson, Micki, Goveia, Michelle G, Mast, T Christopher
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Sprache:eng
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Zusammenfassung:BACKGROUND:Rotavirus is the leading cause of severe diarrhea worldwide in young children. Although rotavirus vaccine efficacy is high in developed countries, efficacy is lower in developing countries. Here, we investigated heterogeneity of rotavirus vaccine efficacy by infant characteristics in developing countries. METHODS:An exploratory, post hoc analysis was conducted using randomized controlled trial data of the pentavalent rotavirus vaccine (RV5) conducted in Africa and Asia (NCT00362648). Infants received either 3 doses of vaccine/placebo and were followed for up to 2 years. Within subgroups, vaccine efficacies and 95% confidence intervals (CIs) against rotavirus gastroenteritis (RVGE) were estimated using Poisson regression. We assessed heterogeneity of efficacy by age at first dose, gender, breastfeeding status and nutrition status. RESULTS:African children receiving the first dose at
ISSN:0891-3668
1532-0987
DOI:10.1097/INF.0000000000001362